Principal Scientist, In Vivo Pharmacology (Full-Time, On-Site)

Location: PineTree Therapeutics, Cambridge, MA
Job Type: Full-Time, on-site
Start Date: Immediate
Department: Translational Research
Reports to: Executive Director, Translational Research
 
PineTree Therapeutics is seeking a seasoned in vivo pharmacologist / vivarium lead to own all rodent efficacy, PK/PD and exploratory toxicology studies that drive our multispecific antibody‑degrader pipeline. You will direct day‑to‑day vivarium operations, author and steward IACUC protocols, and ensure every study is executed to the highest scientific and regulatory standards. While a working knowledge of cell‑based and molecular techniques is valuable, success in this role hinges on exceptional in vivo expertise, study design acumen, and organizational leadership.
 
Key Responsibilities
In Vivo Pharmacology & Study Management
  • Translate project hypotheses into robust animal studies (xenograft, syngeneic, GEMM, PDX, PK/PD, dose‑range finder).
  • Lead or supervise all dosing routes (IP, IV, PO, SC), tumor measurements, and collection of blood/tissue for downstream analyses.
  • Perform power calculations, analyze data in Prism/Spotfire, and present findings to cross‑functional teams and in regulatory documents.
 
Vivarium Operations & Compliance
  • Oversee internal vivarium logistics.
  • Serve as Study Director and primary contact for all IACUC activities—draft, amend, and maintain protocols, train staff in animal welfare regulations and SOPs.
  • Champion a culture of safety, humane care, and continuous improvement.
 
Team Leadership & External Interfaces
  • Mentor in vivo scientists and research associates; provide hands‑on training in rodent techniques and study execution.
  • Manage CRO relationships for overflow or specialized studies; draft/review SOWs, budgets, timelines, and data packages.
  • Partner with DMPK/Tox, CMC, and Regulatory colleagues on IND‑enabling toxicology and bioanalytical plans.
 
Translational Support
  • Advise on, or occasionally perform, cell culture, flow cytometry, IHC, PCR, or CRISPR activities that directly inform in vivo study interpretation or help with new model establishment.
  • Integrate mechanistic readouts (e.g., IHC, RNA‑seq) to enhance translational relevance of animal data.
 
Required Qualifications
  • Ph.D. in Pharmacology, Cancer Biology, or related field with 8+ years of industry experience executing and managing preclinical in vivo studies (or M.S. with 12+ years).
  • Demonstrated mastery of rodent handling, complex dosing techniques, PK/PD sampling, and tumor efficacy models.
  • Deep working knowledge of IACUC, USDA, OLAW, and AAALAC regulations; proven record of authoring and maintaining animal protocols.
  • Experience leading vivarium operations or serving as Study Director across multiple concurrent studies.
  • Strong data analysis skills and fluency with statistical approaches for in vivo datasets.
  • Excellent communication skills with a track record of contributing to IND filings.
  • Proven ability to lead and mentor multidisciplinary teams.
 
Preferred Skills & Experience
  • Background in multispecific antibodies, ADCs, targeted protein degraders, or oncology biologics.
  • Prior oversight of IND‑enabling PK and toxicology packages and CRO management.
  • Familiarity with imaging modalities (IVIS, μCT) and advanced translational assays (CyTOF, spatial transcriptomics).
  • Working knowledge of in vitro molecular biology or cell‑engineering methods that facilitate study interpretation and new model development.
  • Demonstrated success advancing programs from target validation through candidate nomination.
 
Physical Requirements
  • Prolonged periods of sitting at a desk and working on a computer.
  • Prolonged periods of standing and bending.
  • Must be able to lift up to 20 pounds at times.
  • An individual in this position may be exposed to bloodborne pathogens, physical hazards (e.g., needle pricks, etc.), and chemical hazards.

What We Offer
  • Opportunity to drive first‑in‑class antibody degrader therapeutics toward the clinic.
  • Collaborative start‑up environment with direct visibility to executive leadership.
  • Competitive compensation package, equity participation, and comprehensive benefits.
  • Competitive salary and bonus program.
  • Comprehensive benefits including health, dental, and vision insurance
  • 401(k) plan with company matching.
  • Opportunities for professional growth and development in a dynamic biotech environment.


Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.


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